| Date | 1848 |
| Author | Virchow |
| Contribution | With Frerichs, recognized connection between black pigmentation of internal organs and death from malaria. |
| Reference | Bruce-Chwatt |
| Notes | Another example (see 1847) of a pre-germ-theory physical correlate of a particular kind of infection. Cited in Bruce-Chwatt, Essentials of Malariology, 1980. |
| Category | Miscellany |
| Pathogen Class | Protozoa |
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