| Date | 1897 |
| Author | Ehrlich |
| Contribution | Published procedures for standardization of diphtheria antitoxin, and proposed a new antigen-antibody theory. |
| Reference | Silverstein |
| Notes | Reported that the toxin became degraded on storage, to a substance, "toxoid," that was no longer toxic but still capable of combining with antitoxin. It was in this paper that Ehrlich proposed his "side-chain" theory of antigen-antibody interaction. It was enunciated more fully in a lecture published three years later. It was the focus of much debate in the ensuing decades. |
| Category | Immunology |
| Pathogen Class | Bacteria |
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