Details

Date1897
AuthorEhrlich
ContributionPublished procedures for standardization of diphtheria antitoxin, and proposed a new antigen-antibody theory.
ReferenceSilverstein
NotesReported that the toxin became degraded on storage, to a substance, "toxoid," that was no longer toxic but still capable of combining with antitoxin. It was in this paper that Ehrlich proposed his "side-chain" theory of antigen-antibody interaction. It was enunciated more fully in a lecture published three years later. It was the focus of much debate in the ensuing decades.
CategoryImmunology
Pathogen ClassBacteria

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