| Date | 1888 |
| Author | Nuttall |
| Contribution | Reported that anthrax bacilli, if not too numerous, are killed by normal serum (from non-immune animals). |
| Reference | Lechevalier |
| Notes | This was not the first report of the bactericidal action of serum, but was a major and influential contribution to the concept of humoral immunity, which was now mounting in opposition to the concept of phagocytosis. Some critics were contending that leucocytes merely took up dead bacteria. |
| Category | Immunology |
| Pathogen Class | Bacteria |
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