|Contribution||Published major medical textbook, fully accepting the germ theory.|
|Notes||J. Bristowe. His Theory and Practice of Medicine reflected the recent scientific advances in chemistry, microscopy, cellular pathology and bacteriology. He recognized the reported bacterial etiology of diphtheria, cholera and tuberculosis, and predicted similar causation for other diseases. Bynum contrasts this book with Graves' Clinical Lectures of 1848, with its pre-germ-theory medicine, and its treatment of fever as a general disease category rather than the symptom that it became in the writings on Bristowe and later writers.|
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