| Date | 1893 |
| Author | Buchner |
| Contribution | Reported that serum does not kill bacteria if it is heated to 56°C. |
| Reference | Silverstein |
| Notes | He called the putative heat-labile substance "alexine" (superseded by "complement"). Silverstein gives date of discovery (publication) as 1889. See 1895. |
| Category | Immunology |
| Pathogen Class | Bacteria |
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