| Date | 1883 |
| Author | Pasteur |
| Contribution | a. With Thuillier, reported that passage of swine-fever microbe through rabbits decreased its virulence for swine. |
| Reference | Bullock |
| Notes | Geison notes that attenuation was tantamount to production of a vaccine. Pasteur had already shown that serial passage results in decrease or increase in virulence, depending on the host species used for passage. |
| Category | Miscellany |
| Pathogen Class | General |
Copyright © 2007- William C. Campbell. All rights reserved.