| Date | 1878 |
| Author | Pasteur |
| Contribution | a. Confirmed microorganisms as cause of flacherie in silkworms. |
| Reference | Carter |
| Notes | He inoculated silkworms with microorganisms that caused fermentation of mulberry leaves in the gut, and showed that the disease developed when, and only when, fermented leaves were present. According to Carter, this was Pasteur's most explicit demonstration of sufficient and necessary causation (although he did not use such terms until 1881). Note that Carter gives both 1877 and 1878 in this context, but his references cite the latter. Perhaps demonstrated at a congress in the earlier year and published in the later year. |
| Category | Causation |
| Pathogen Class | General |
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