ContributionPresented evidence for the particulate nature of the cowpox agent.
NotesChauveau J.B.A. of France did this work, which stimulated others to investigate disease causation. See Loeffler 1887, Howard trranslation, page 96, and especially Howard's valuable note on page 315. Chauveau layered water over vaccine lymph or Glanders pus. After standing for a day, the soluble components diffused into the water, while the solid materials stayed on the bottom. These solids, we now know, would have included vaccinia virus attached to celluar detritus and other insoluble materials. Chaveau showed that infectivity belonged only to the particute materal and did not have the nature of a fluid 'poison.'
Pathogen ClassViruses

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