| Date | 1894 |
| Author | Pfeiffer |
| Contribution | With Isayev, reported that cholera germs die in peritoneal cavity of immune, but not in normal, guinea-pig. |
| Reference | Norman |
| Notes | R. F. I. Pfeiffer and V. I. Isayev (sometimes given as Issaell). The effect is known as "Pfeifer's phenomenon." Cholera organisms in peritoneal cavity of normal guinea pigs multiply and kill the host; but in cavity of immune guinea pig, they round up and clump (and die). Silverstein gives an 1895 publication. |
| Category | Immunology |
| Pathogen Class | Bacteria |
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